The Epidermis is constantly renewing itself from the bottom up. Stem cells create new skin cells at the bottom of the epidermis, pushing the older cells up towards the surface. At the surface, the oldest cells die and flake off. This mechanism works to make any surface ink, even a Sharpie moustache, eventually wear off.
How to Remove Highlighter Stains from Skin Often when you have a big exam coming up the next day, it is a good idea to highlight the important points on your book. However, there are times when you get so absorbed in the book that you do not notice the highlighter stains on your hands and arms.