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A therapy addressed to the circulating antibodies is plasmapheresis, which removes 52- and 60-kDa anti-Ro/SSA and anti-La/SSB antibodies. The second-degree block seems to recede after this treatment. Unfortunately, even if the levels of antibodies decrease, the already established third-degree block does not regress [ 97 , 98 ].

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SSB-1 is located, though, over a wider region of the nucleolus than the transcription site marker. Immunoprecipitations of yeast cell extracts with the SSB-1 antibody reveal that in 150 mM NaCl SSB-1 is bound to two small nuclear RNAs (snRNAs). These yeast snRNAs are snR10 and snR11, with snR10 being predominant.

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SSB/La autoantibodies in women with autoimmune diseases. We report a case of an isolated congenital AVB with cardiomegaly and pericardial effusion in a woman who had both serum anti-SSA/Ro and anti-SSB/La antibodies, but had no clinical or laboratory evidence of autoimmune diseases. Recombinant Antibody Network (RAN) is an international tri-center consortium that develops renewable and highly validated recombinant antibodies.

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Antibody, a protective protein produced by the immune system in response to the presence of a foreign substance, called an Learn more about the function and structure of antibodies in this article.

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Anti-GQ1b antibodies are seen in more than 80% of patients with Miller-Fisher syndrome and may be elevated in GBS patients with ophthalmoplegia. The role of isolated anti-GM2 antibodies is unknown. These tests by themselves are not diagnostic and should be used in conjunction with other clinical parameters to confirm disease.

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